Collaborations between researchers and companies offer significant opportunities for advancing empirical economic research. To fully harness this potential, it is essential to understand mutual incentives, recognize the value of data, and identify promising win-win scenarios for both parties. Tailored Business-to-Science (B2S) cooperation models play a crucial role in fostering successful partnerships and driving impactful research. This panel will explore the opportunities and challenges of B2S collaboration models, highlighting key framework conditions for success and sustainable data provision. Experts from research institutions, science initiatives, and funding organizations will share insights and best practices to promote effective and sustainable cooperation.